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embargoed abstractSIS 1 · The DNA damage and DNA replication stress responses
Thursday .::. 27 September .::. 14:00-16:00SIS.1 · 0+P1 
Methods for detecting checkpoint activation in response to UV, and other genotoxic agents in yeast and mammalian cells
F. Marini, M. Giannattasio, F. Lazzaro, P. Plevani, M.M. Falconi
Dip. Scienze Biomolecolari e Biotecnologie, Univ. degli Studi di Milano (Milan)
SIS.1 · 0+P2
DNA replication and genome stability: the role of ATM, ATR and the Mre11 complex
V. Costanzo
CanceResearchUK, London Research Inst., Clare Hall Laboratories (London, United Kingdom)
SIS.1 · 0+P3
Formation and dynamics of macromolecular protein complexes in response to DNA replication stress: analysis by Blue Native PAGE
A. Franchitto
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
SIS.1 · 0+P4
Analysis of yeast DNA repair helicases roles in preventing recombination at replication forks using 2D gels technique
W. Carotenuto, M. Saponaro, I. Chiolo, A. Alzu, G. Liberi
FIRC Inst. Molecular Oncology Foundation (Milan)
SIS.1 · 0+P5
A ChIP on chip platform specific for DNA-damage
R. Mantovani1, M. Ceribelli1, L. Lorenzi3, F. Goeman2, G. Piaggio3, M.A. Viganò1
1DSBB (Milan); 2CRS Istituto Regina Elena (Rome); 3Genespin Srl (Milan)
SIS.1 · 0+P6
Live cell imaging and intracellular dynamics of fluorescent proteins involved in the DNA damage response
M.C. Cardoso
Max Delbrueck Center for Molecular Medicine (Berlin, Germany)
SIS.1 · 0+P7
Analysis of checkpoints/DNA repair protein interaction at the chromatin level: biochemical and immunofluorescence approaches
O. Cazzalini1, P. Perucca1, M. Savio1, L.A. Stivala1, A.I. Scovassi2, E. Prosperi2
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Istituto di Genetica Molecolare, CNR (Pavia)
SIS.1 · P8
Role of the base excision repair gene myh in a mouse model of colonic inflammation
G. de Luca1, I. Casorelli1, F. Chiera1, T. Pannellini2, P. Musiani2, A. Butera3, M. Boirivant3, M. Bignami1
1Dept of Environment and Primary Prevention , Istituto Superiore Sanità (Rome); 2Aging Research Center "Gabriele D'Annunzio", Univ. of Chieti (Chieti); 3Dept of Infectious Parassitic and Immuno-mediated Diseases,Istituto Superiore di Sanità (Rome)
SIS.1 · P9
High susceptibility of newborn mice to DNA damage
C. Cartiglia, M. Longobardi, A. Izzotti, G. Travaini, R.T. Micale, T.M. Pennisi, S. de Flora
Dept Health Sciences, Univ. Genoa (Genova)
SIS.1 · P10
Downregulation of DNA repair in poplar non-proliferating cells under UV-B radiation
G. Emiliani, R. Giannini, D. Paffetti
Dept Environmental and Forestry technologies and Sciences - Univ. Florence (Florence)
SIS.1 · P11
Functional analysis of the role of Exo1 in response to DNA damage in yeast and human cells
S. Sertic, M. Giannattasio, F. Puddu, P. Plevani, M. Muzi Falconi, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milan)
SIS.1 · P12
The MUS81 endonuclease processes stalled forks into DSBs and is required in WS cells for recovery from replication arrest
A. Franchitto1, L.M. Pirzio1, E. Prosperi2, O. Sapora1, M. Bignami1, P. Pichierri1
1Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome); 2Istituto di Genetica Molecolare, CNR (Pavia)
SIS.1 · P13
The Werner syndrome helicase activity is essential in maintaining fragile site stability
L.M. Pirzio, P. Pichierri, M. Bignami, A. Franchitto
Istituto Superiore di Sanità, Section of Experimental and Computational Carcinogenesis (Rome)
SIS.1 · P14
Functional characterization of the Fanconi anemia complex
E. Tumini, D. Agnesi, M. Muzi Falconi, P. Plevani, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milano)
SIS.1 · P15
Analysis of the functional interplay between the Werner syndrome protein and the replication checkpoint
F. Ammazzalorso, L.M. Pirzio, L. Cignolo, M. Bignami, A. Franchitto, P. Pichierri
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
SIS.1 · P16
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
L. Muzzolini1, F. Beuron2, A. Patwardhan2, V. Popuri1, S. Cui1, B. Niccolini1, P. Freemont2, A. Vindigni1
1ICGEB (Trieste); 2Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London (London, United Kingdom)
SIS.1 · 0+P1
Methods for detecting checkpoint activation in response to UV, and other genotoxic agents in yeast and mammalian cells
F. Marini, M. Giannattasio, F. Lazzaro, P. Plevani, M.M. Falconi
Dip. Scienze Biomolecolari e Biotecnologie, Univ. degli Studi di Milano (Milan)
Methods for detecting checkpoint activation in response to UV, and other genotoxic agents in yeast and mammalian cells
F. Marini, M. Giannattasio, F. Lazzaro, P. Plevani, M.M. Falconi
Dip. Scienze Biomolecolari e Biotecnologie, Univ. degli Studi di Milano (Milan)
SIS.1 · 0+P2
DNA replication and genome stability: the role of ATM, ATR and the Mre11 complex
V. Costanzo
CanceResearchUK, London Research Inst., Clare Hall Laboratories (London, United Kingdom)
DNA replication and genome stability: the role of ATM, ATR and the Mre11 complex
V. Costanzo
CanceResearchUK, London Research Inst., Clare Hall Laboratories (London, United Kingdom)
SIS.1 · 0+P3
Formation and dynamics of macromolecular protein complexes in response to DNA replication stress: analysis by Blue Native PAGE
A. Franchitto
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
Formation and dynamics of macromolecular protein complexes in response to DNA replication stress: analysis by Blue Native PAGE
A. Franchitto
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
SIS.1 · 0+P4
Analysis of yeast DNA repair helicases roles in preventing recombination at replication forks using 2D gels technique
W. Carotenuto, M. Saponaro, I. Chiolo, A. Alzu, G. Liberi
FIRC Inst. Molecular Oncology Foundation (Milan)
Analysis of yeast DNA repair helicases roles in preventing recombination at replication forks using 2D gels technique
W. Carotenuto, M. Saponaro, I. Chiolo, A. Alzu, G. Liberi
FIRC Inst. Molecular Oncology Foundation (Milan)
SIS.1 · 0+P5
A ChIP on chip platform specific for DNA-damage
R. Mantovani1, M. Ceribelli1, L. Lorenzi3, F. Goeman2, G. Piaggio3, M.A. Viganò1
1DSBB (Milan); 2CRS Istituto Regina Elena (Rome); 3Genespin Srl (Milan)
A ChIP on chip platform specific for DNA-damage
R. Mantovani1, M. Ceribelli1, L. Lorenzi3, F. Goeman2, G. Piaggio3, M.A. Viganò1
1DSBB (Milan); 2CRS Istituto Regina Elena (Rome); 3Genespin Srl (Milan)
SIS.1 · 0+P6
Live cell imaging and intracellular dynamics of fluorescent proteins involved in the DNA damage response
M.C. Cardoso
Max Delbrueck Center for Molecular Medicine (Berlin, Germany)
Live cell imaging and intracellular dynamics of fluorescent proteins involved in the DNA damage response
M.C. Cardoso
Max Delbrueck Center for Molecular Medicine (Berlin, Germany)
SIS.1 · 0+P7
Analysis of checkpoints/DNA repair protein interaction at the chromatin level: biochemical and immunofluorescence approaches
O. Cazzalini1, P. Perucca1, M. Savio1, L.A. Stivala1, A.I. Scovassi2, E. Prosperi2
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Istituto di Genetica Molecolare, CNR (Pavia)
Analysis of checkpoints/DNA repair protein interaction at the chromatin level: biochemical and immunofluorescence approaches
O. Cazzalini1, P. Perucca1, M. Savio1, L.A. Stivala1, A.I. Scovassi2, E. Prosperi2
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Istituto di Genetica Molecolare, CNR (Pavia)
SIS.1 · P8
Role of the base excision repair gene myh in a mouse model of colonic inflammation
G. de Luca1, I. Casorelli1, F. Chiera1, T. Pannellini2, P. Musiani2, A. Butera3, M. Boirivant3, M. Bignami1
1Dept of Environment and Primary Prevention , Istituto Superiore Sanità (Rome); 2Aging Research Center "Gabriele D'Annunzio", Univ. of Chieti (Chieti); 3Dept of Infectious Parassitic and Immuno-mediated Diseases,Istituto Superiore di Sanità (Rome)
Role of the base excision repair gene myh in a mouse model of colonic inflammation
G. de Luca1, I. Casorelli1, F. Chiera1, T. Pannellini2, P. Musiani2, A. Butera3, M. Boirivant3, M. Bignami1
1Dept of Environment and Primary Prevention , Istituto Superiore Sanità (Rome); 2Aging Research Center "Gabriele D'Annunzio", Univ. of Chieti (Chieti); 3Dept of Infectious Parassitic and Immuno-mediated Diseases,Istituto Superiore di Sanità (Rome)
SIS.1 · P9
High susceptibility of newborn mice to DNA damage
C. Cartiglia, M. Longobardi, A. Izzotti, G. Travaini, R.T. Micale, T.M. Pennisi, S. de Flora
Dept Health Sciences, Univ. Genoa (Genova)
High susceptibility of newborn mice to DNA damage
C. Cartiglia, M. Longobardi, A. Izzotti, G. Travaini, R.T. Micale, T.M. Pennisi, S. de Flora
Dept Health Sciences, Univ. Genoa (Genova)
SIS.1 · P10
Downregulation of DNA repair in poplar non-proliferating cells under UV-B radiation
G. Emiliani, R. Giannini, D. Paffetti
Dept Environmental and Forestry technologies and Sciences - Univ. Florence (Florence)
Downregulation of DNA repair in poplar non-proliferating cells under UV-B radiation
G. Emiliani, R. Giannini, D. Paffetti
Dept Environmental and Forestry technologies and Sciences - Univ. Florence (Florence)
SIS.1 · P11
Functional analysis of the role of Exo1 in response to DNA damage in yeast and human cells
S. Sertic, M. Giannattasio, F. Puddu, P. Plevani, M. Muzi Falconi, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milan)
Functional analysis of the role of Exo1 in response to DNA damage in yeast and human cells
S. Sertic, M. Giannattasio, F. Puddu, P. Plevani, M. Muzi Falconi, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milan)
SIS.1 · P12
The MUS81 endonuclease processes stalled forks into DSBs and is required in WS cells for recovery from replication arrest
A. Franchitto1, L.M. Pirzio1, E. Prosperi2, O. Sapora1, M. Bignami1, P. Pichierri1
1Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome); 2Istituto di Genetica Molecolare, CNR (Pavia)
The MUS81 endonuclease processes stalled forks into DSBs and is required in WS cells for recovery from replication arrest
A. Franchitto1, L.M. Pirzio1, E. Prosperi2, O. Sapora1, M. Bignami1, P. Pichierri1
1Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome); 2Istituto di Genetica Molecolare, CNR (Pavia)
SIS.1 · P13
The Werner syndrome helicase activity is essential in maintaining fragile site stability
L.M. Pirzio, P. Pichierri, M. Bignami, A. Franchitto
Istituto Superiore di Sanità, Section of Experimental and Computational Carcinogenesis (Rome)
The Werner syndrome helicase activity is essential in maintaining fragile site stability
L.M. Pirzio, P. Pichierri, M. Bignami, A. Franchitto
Istituto Superiore di Sanità, Section of Experimental and Computational Carcinogenesis (Rome)
SIS.1 · P14
Functional characterization of the Fanconi anemia complex
E. Tumini, D. Agnesi, M. Muzi Falconi, P. Plevani, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milano)
Functional characterization of the Fanconi anemia complex
E. Tumini, D. Agnesi, M. Muzi Falconi, P. Plevani, F. Marini
Dept Biomolecular Science and Biotechnology, Univ. Milan (Milano)
SIS.1 · P15
Analysis of the functional interplay between the Werner syndrome protein and the replication checkpoint
F. Ammazzalorso, L.M. Pirzio, L. Cignolo, M. Bignami, A. Franchitto, P. Pichierri
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
Analysis of the functional interplay between the Werner syndrome protein and the replication checkpoint
F. Ammazzalorso, L.M. Pirzio, L. Cignolo, M. Bignami, A. Franchitto, P. Pichierri
Section of Experimental Carcinogenesis, Istituto Superiore di Sanità (Rome)
SIS.1 · P16
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
L. Muzzolini1, F. Beuron2, A. Patwardhan2, V. Popuri1, S. Cui1, B. Niccolini1, P. Freemont2, A. Vindigni1
1ICGEB (Trieste); 2Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London (London, United Kingdom)
Different quaternary structures of human RECQ1 are associated with its dual enzymatic activity
L. Muzzolini1, F. Beuron2, A. Patwardhan2, V. Popuri1, S. Cui1, B. Niccolini1, P. Freemont2, A. Vindigni1
1ICGEB (Trieste); 2Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London (London, United Kingdom)