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embargoed abstractPMS 9 · Cell cycle, oncogenes and tumor suppressors
Friday .::. 28 September .::. 14:00-16:00PMS.9 · 0+P1 
pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation
E. Mezzaroma, F. De Santa, S. Albini, G. De Luca , A. Felsani, M. Caruso
CNR-Istituto Neurobiologia e Medicina Molecolare (Roma)
PMS.9 · 0+P2
Positive and negative regulation of Myc mediated transcription
B. Gargano, S. Amente, M. Fiorillo, L. Lania, B. Majello
Dept Structural and Functional Biology Univ. Naples "Federico II" (Naples)
PMS.9 · 0+P3
STAT3 and Her2 cooperate in mammary tumorigenesis
S. Pensa1, I. Barbieri1, V. Fagiano1, T. Pannellini2, P. Musiani2, V. Poli1
1Molecular Biotechnology Center, Dept Genetics Biology and Biochemistry, Univ. Turin (Turin); 2Ce.S.I., Anatomia Patologica, Univ. G. D'Annunzio (Chieti)
PMS.9 · 0+P4
CDK4 is a direct MYCN target in neuroblastoma
C. Rizzato1, J. Batzler2, D. Muth2, A. Benner3, M. Fischer4, B. Brors3, M. Schwab2, F. Westermann2
1Dept Biology, Univ. Pisa; Division of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 2Dept of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 3Dept of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 4Children's Hospital, Dept of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), Univ. of Cologne (Cologne, Germany)
PMS.9 · 0+P5
Kinetochore-associated RanGTP regulates kinetochore-dependent microtubule nucleation in centrosome-containing cells
L. Torosantucci, M. de Luca, G. Guarguaglini, P. Lavia, F. Degrassi
Istituto Biologia e Patologia Molecolari CNR, Univ. "La Sapienza" (Rome)
PMS.9 · 0+P6
Micronuclei generation and chromosomal instability after RB interference in human fibroblasts
A. Amato, L. Lentini, T. Schillaci, A. Di Leonardo
Dept of Cellular and Developmental Biology (Palermo)
PMS.9 · 0+P7
Eukaryotic initiation Factor 6 is a rate-limiting controller of translation, growth and tumorigenesis
V. Gandin1, A. Miluzio1, A. Barbieri1, L. Magri1, P.C. Marchisio1, H. Kiyokawa2, S. Biffo1,3
1Molecular Histology and Cell Growth Unit, DIBIT-San Raffaele Hospital (Milan); 2Northwestern Univ, Feinberg School of Medicine (Chicago, USA); 3DISAV, Univ. Eastern Piedmont (Alessandria)
PMS.9 · 0+P8
Interplay of Calmodulin, FADD and Casein Kinase Iα in apoptosis and mitosis
G. Papoff1, N. Trivieri1, R. Crielesi1, F. Ruberti2, S. Marsilio1, G. Ruberti1
1Istituto di Biologia Cellulare, CNR (Monterotondo); 2Istituto di Neurobiologia e Medicina Molecolare, CNR (Rome)
PMS.9 · P9
RanBP1 regulates mitotic microtubule stability and chromosome segregation
M. Ciciarello1, R. Mangiacasale1, A. Tedeschi1,2, E. Roscioli1, W. Rensen1, P. Lavia1
1Inst. Molecular Biology and Pathology, National Research Council, c/o Univ. Rome "La Sapienza" (Rome); 2Research Institute of Molecular Pathology (IMP) (Vienna, Austria)
PMS.9 · P10
Delayed entry to quiescence in p21CDKN1A-null human fibroblasts: a possible involvement of DNA damage checkpoint
P. Perucca1, O. Cazzalini1, M. Savio1, T. Coppa1, R.A.L. Laskey3, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic, CNR (Pavia); 3Hutchison/MRC Research Centre (Cambridge, United Kingdom)
PMS.9 · P11
The involvement of the proteasomal protein Rpn11 in the FEAR pathway activation and in rDNA segregation in S. cerevisiae
T. Rinaldi, M. Esposito, L. Frontali
Dept Cell and Developmental Biology (Rome)
PMS.9 · P12
Interplay between typical and atypical Arabidopsis E2Fs in cell cycle progression and development
C. Maggio1, R. Sozzani1, L. Concia1, P. Longoni1, C. Bergounioux2, R. Giordo3, D. Albani3, R. Cella1
1Dip. di Genetica e Microbiologia (Pavia); 2Inst. of Plant Biotechnology (Orsay, France); 3Dip. di Botanica ed Ecologia Vegetale (Sassari)
PMS.9 · P13
Uncapped telomeres activate multiple cell cycle checkpoints in Drosophila
M. Musarò1, L. Ciapponi2, B. Fasulo3, M. Gatti2, G. Cenci1
1DiSTeBA (Lecce); 2Dip. di Genetica e Biologia Molecolare, Univ. di Roma "La Sapienza" (Rome); 3Molecular Cell and Developmental Biology, Univ. of California (Santa Cruz, CA, USA)
PMS.9 · P14
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts
L. Lentini, L. Insalaco, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
PMS.9 · P15
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture
L. Insalaco, L. Lentini, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
PMS.9 · P16
Antiproliferative activity of the new Resveratrol-derivative 4, 4’-dihydroxy-stilbene
L. Bianchi1, M. Savio1, T. Coppa1, O. Cazzalini1, M.C. Lazzč1, P. Perruca1, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic,CNR (Pavia)
PMS.9 · P17
Differenet intracellular pathways are involved in mitosis dysregulation induced by HCV and ethanol
C. Balsano1,2, A. Alisi1,2, M. Ghidinelli1,2, A. Spaziani1,2
1Dept Medicina Interna e Sanità Pubblica (L'Aquila); 2 A. Cesalpino Foundation (Rome )
PMS.9 · P18
Thyroid hormone T3 : dual effect on proliferation in human endocrine tumor cells
S. Michienzi1,2, G. Moriggi1,2, C. Verga Falzacappa1,2, V. Patriarca1,2, C. Mangialardo1,2, A. Stigliano1,2, V. Toscano1, S. Misiti1,2
1Chair of Endocrinology, II Faculty of Medicine, Sapienza, Univ. Rome (Rome); 2Centro Ricerca AFaR, Ospedale San Pietro FBF (Rome)
PMS.9 · P19
The cytoplasmic tyrosine kinase Fes is a crucial mediator of the EGFR signaling in neuroblastoma cells
E. Brunelli, I. Gnemmi, L. Mercantili, G. Pinton, P.L. Canonico, F. Condorelli, L. Moro
Dept DiSCAFF (Novara)
PMS.9 · P20
Role of Ng2 and Olig2 in PDGF-B induced mouse oligodendroglioma model
M. Terrile1,2, I. Apolloni1,2, P. Malatesta1,2
1National Inst. for Cancer Reasearch (Genoa); 2Dept of Oncology, Biology and Genetics (Genoa)
PMS.9 · P21
AP-2α and AP-2γ regulate chemotherapy-induced apoptosis in epithelial tumors
E. Penna1, F. Orso1, P. Sismondi1, M. de Bortoli1,2, D. Taverna1,2
1Dept Oncological Science, Univ. Torino and Inst. for Cancer Research and Treatment (IRCC) (Torino); 2Centro Interdipartimentale Sistemi Complessi in Biologia e Medicina Molecolare c/o DBAU (Torino)
PMS.9 · P22
Different functional role of V600E BRAF mutation in acquired nevi and cutaneous melanomas
M. Scatolini1, M. Mellogrand1, F. Acquadro3, E. Grosso1,2, T. Venesio4, M. Risio4, G. Chiorino1
1Fondo Edo Tempia (Biella); 2SysBiom (Turin); 3C.N.I.O. (Madrid, Spain); 4I.R.C.C. (Candiolo)
PMS.9 · P23
AcP1 gene and cancerogenesis.
D. Cirelli1, E. Caproni1, R. Marzocchini1, F. Malentacchi2, G. Pepe3, G. Raugei1
1Dept Biochemical Sciences, Univ. Florence (Florence); 2Dept Clinical Physiopathology, Univ. Florence (Florence); 3Dept Medical and Surgical Critical Care, Univ. Florence (Florence)
PMS.9 · P24
Inflammation-associated centrosomal lesions in esophageal stem cells and their progenies
D. Segat1, E. Dazzo1, M. Cassaro2, C. Romualdi1, M. Rugge3, E. Ancona3, G. Zaninotto4, M.D. Baroni1
1Dept of Biology, Univ. Padua (Padua); 2Dept of Oncological and Surgical Science, Univ. of Padua (Padua); 3Dept of Endoscopy and Pathology and Dept of Surgery, Istituto Oncologico Veneto I.R.C.S.S. (Padua); 4Dept of General Surgery, S. Giovanni e Paolo Hospital (Venice)
PMS.9 · P25
Targeting ID proteins with an HLH mutant domain triggers neuronal commitment and differentiation of NB cells
D. Annibali1, R. Ciarapica2, R. Rota2, S. Nasi1
1IBPM, CNR (Rome); 2Ospedale Pediatrico Bambino Gesù (Roma)
PMS.9 · P26
New tools for study and treatment of malignant pleural mesothelioma
S. Soligon1, A. Daga2, L. Mutti3, G. Corte2, G. Gaudino1
1DISCAFF, Univ. del Piemonte Orientale (Novara); 2Univ. of Genoa, IST (Genoa); 3ASL 11 (Vercelli)
PMS.9 · P27
Antiproliferative and proapoptotic effects of a new combi-molecule on non small cell lung cancer cell lines
R. Alfieri1, A. Cavazzoni1, C. Carmi2, M. Galetti1, V. Zuliani2, C. Fumarola1, M. Mor2, P.G. Petronini1
1Dept Experimental Medicine, Univ. Parma (Parma); 2Pharmaceutical Dept, Univ. Parma (Parma)
PMS.9 · P28
Keratinocyte cultures from involved skin in vitiligo patients show an impaired in vitro behaviour
E. Migliore, S. Bondanza, R. Maurelli, P. Paterna, G. Primavera, E. Paionni, E. Dellambra, L. Guerra
IDI-IRCSS Roma, Lab. Ing. Tissut. e Fisiopat. Cutanea (Rome)
PMS.9 · P29
Impaired differentiation in plantar keratinocytes from Rspo mutated - XX sex reversal patient
L. Panacchia1, O. Radi2, P. Parma2, S. Bondanza1, R. Maurelli1, E. Dellambra1, G. Camerino2, L. Guerra1
1Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI-IRCCS, Pomezia (Rome); 2Dip. di Patologia Umana ed Ereditaria, Sezione di Biologia Generale e Genetica Medica, Univ. di Pavia (Pavia)
PMS.9 · P30
Haplotypes and activities of the internal promoter for the isoform ΔN133 of TP53
I. Bellini1, L. Pitto2, G. Rainaldi2, F. Gemignani1, S. Landi1
1Dip. Biologia, Univ. Pisa (Pisa); 2Istituto di Fisiologia Clinica del CNR di Pisa (Pisa)
PMS.9 · P31
Molecular combing for the detection of rearrangements involving the human APC locus
V. Biscaro1, M. Bensi1, E. Molino1, A. Castelli1, L. Varesco2, G.N. Ranzani1, E. Raimondi1
1Dept Genetics and Microbiology, Univ. Pavia (Pavia); 2Natl Inst Cancer Res (Genoa)
PMS.9 · P32
Knock down of ATM and ATR induces p53 displacement from centrosomes in human primary cells
R. Burla1, P. Caruso1, S. Piersanti1,2, C. Remoli1,2, E. Cundari1,3, I. Saggio1,2,3
1Dept of Genetics and Molecular Biology, Univ. of Rome "La Sapienza” (Rome); 2Fondazione Parco San Raffaele (Rome); 3IBPM CNR (Rome)
PMS.9 · P33
Biochemical and immunohistochemical characterization of human RNASET2 expression
P. Campomenosi1, S. Salis1, C. Riva2, S. Marchet2, L. Giuliani1, C. Lindqvist3, F. Acquati1, L. Monti1, C. Capella2, R. Taramelli1
1Dept Biotechnologies and Molecular Sciences, Univ. Insubria (Varese); 2Dept of AnathomoPathology, Univ. of Insubria (Varese); 3Dept of Biochemistry and Pharmacy, Abo Akademi Univ. (Turku, Finland)
PMS.9 · P34
HIPK2 contributes to the divergent cell responses elicited by the specific p53 inducers RITA and Nutlin-3
C. Rinaldo1, A. Prodosmo1, F. Siepi1, A. Sacchi1, G. Selivanova2, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst. (Rome); 2Dept Microbiology, Tumor and Cell Biology, Karolinska Inst (Stockholm, Sweden)
PMS.9 · P35
p53-independent mechanisms of HIPK2 induced sensitivity to antineoplastic drugs
C. Lazzari1, A. Prodosmo1, A. Costanzo2, A. Sacchi1, L. Guerrini3, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst (Roma); 2Dept Dermatology, Univ. Tor Vergata Rome (Rome); 3Dept Biomolecular and Biotechnological Sciences, Univ. Milan (MIlan)
PMS.9 · P36
PRDM1/BLIMP1 & PRDM2/RIZ in T CD4+ naïve lymphocytes activation
L. de Felice1, C. de Rosa1, M. Pacifico1, E. Di Zazzo1, N. Medici1, B. Moncharmont2, G. Matarese3, C. Abbondanza1
1Dip. Patologia generale, Seconda Univ. Napoli (Napoli); 2Dip. di Scienze per la Salute, Univ. degli Studi del Molise (Campobasso); 3Ist. di Endocrinologia e Oncologia Sperimentale, CNR (Napoli)
PMS.9 · P37
8-prenylnaringenin inhibits epidermal growth factor induced MCF-7 breast cancer cells proliferation targeting PI3K activity
G. Pinton, E. Brunelli, A. Minassi, G. Appendino, L. Moro
Dept DiSCAFF (Novara)
PMS.9 · P38
Study of the biological action of two tomato cysteine-rich peptides on human endothelial and carcinoma cells
C. Cavallini1, B. Molesini1, M. Vezzalini3, C. Sorio3, P. Delva4, P. Minuz4, T. Pandolfini2, A. Spena1
1Dept Scientific Technological, Univ. Verona (Verona); 2Dept DiSTeMeV, Univ. of Verona (Verona); 3Dept of Pathology, Univ. of Verona (Verona); 4Dept Biomedical and Surgical Sciences, Univ. of Verona (Verona)
PMS.9 · P39
Corylus avellana species as a new source of Taxol and taxanes to be used as antimitotic drug
L. Ottaggio1, F. Bestoso2, M. Sancandi2, M. Miele2,3
1National Inst. for Cancer Research (Genova); 2Laboratory of Plant and Pharmaceutical Biotechnology, Advanced Biotechnology Center (ABC) (Genova); 3Dept of Pharmaceutical Sciences, Univ. of Genova (Genova)
PMS.9 · P40
Diacylglycerol kinase is required for estrogen-induced proliferation, motility, and anoikis of endometrial cancer cells
I. Gregnanin1, P.E. Porporato2, B. Perego1, F. Chianale2, A. Romano1, A. Graziani2, N. Surico1, N. Filigheddu1
1Dept Clinical and Experimental Medicine, Univ Piemonte Orientale (Novara); 2Dept Medical Sciences, Univ Piemonte Orientale (Novara)
PMS.9 · P41
Loss of Chp-1 (CHORD-containing protein 1) results in early embryonic lethality due to aneuploidy and mitotic defects
R. Ferretti1, V. Palumbo2, A. Di Savino1, S. Velasco1, S. Bonaccorsi2, M. Gatti2, G. Tarone1, M. Brancaccio1
1Dip. Genetica, Biologia e Biochimica, Univ. Torino (Turin); 2Insitute of Biology and Molecular Pathology CNR, and Dept of Genetics and Molecular Biology, Univ. of Rome “La Sapienza” (Rome)
PMS.9 · 0+P1
pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation
E. Mezzaroma, F. De Santa, S. Albini, G. De Luca , A. Felsani, M. Caruso
CNR-Istituto Neurobiologia e Medicina Molecolare (Roma)
pRb-dependent cyclin D3 protein stabilization is required for myogenic differentiation
E. Mezzaroma, F. De Santa, S. Albini, G. De Luca , A. Felsani, M. Caruso
CNR-Istituto Neurobiologia e Medicina Molecolare (Roma)
PMS.9 · 0+P2
Positive and negative regulation of Myc mediated transcription
B. Gargano, S. Amente, M. Fiorillo, L. Lania, B. Majello
Dept Structural and Functional Biology Univ. Naples "Federico II" (Naples)
Positive and negative regulation of Myc mediated transcription
B. Gargano, S. Amente, M. Fiorillo, L. Lania, B. Majello
Dept Structural and Functional Biology Univ. Naples "Federico II" (Naples)
PMS.9 · 0+P3
STAT3 and Her2 cooperate in mammary tumorigenesis
S. Pensa1, I. Barbieri1, V. Fagiano1, T. Pannellini2, P. Musiani2, V. Poli1
1Molecular Biotechnology Center, Dept Genetics Biology and Biochemistry, Univ. Turin (Turin); 2Ce.S.I., Anatomia Patologica, Univ. G. D'Annunzio (Chieti)
STAT3 and Her2 cooperate in mammary tumorigenesis
S. Pensa1, I. Barbieri1, V. Fagiano1, T. Pannellini2, P. Musiani2, V. Poli1
1Molecular Biotechnology Center, Dept Genetics Biology and Biochemistry, Univ. Turin (Turin); 2Ce.S.I., Anatomia Patologica, Univ. G. D'Annunzio (Chieti)
PMS.9 · 0+P4
CDK4 is a direct MYCN target in neuroblastoma
C. Rizzato1, J. Batzler2, D. Muth2, A. Benner3, M. Fischer4, B. Brors3, M. Schwab2, F. Westermann2
1Dept Biology, Univ. Pisa; Division of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 2Dept of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 3Dept of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 4Children's Hospital, Dept of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), Univ. of Cologne (Cologne, Germany)
CDK4 is a direct MYCN target in neuroblastoma
C. Rizzato1, J. Batzler2, D. Muth2, A. Benner3, M. Fischer4, B. Brors3, M. Schwab2, F. Westermann2
1Dept Biology, Univ. Pisa; Division of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 2Dept of Tumor Genetics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 3Dept of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) (Heidelberg, Germany); 4Children's Hospital, Dept of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), Univ. of Cologne (Cologne, Germany)
PMS.9 · 0+P5
Kinetochore-associated RanGTP regulates kinetochore-dependent microtubule nucleation in centrosome-containing cells
L. Torosantucci, M. de Luca, G. Guarguaglini, P. Lavia, F. Degrassi
Istituto Biologia e Patologia Molecolari CNR, Univ. "La Sapienza" (Rome)
Kinetochore-associated RanGTP regulates kinetochore-dependent microtubule nucleation in centrosome-containing cells
L. Torosantucci, M. de Luca, G. Guarguaglini, P. Lavia, F. Degrassi
Istituto Biologia e Patologia Molecolari CNR, Univ. "La Sapienza" (Rome)
PMS.9 · 0+P6
Micronuclei generation and chromosomal instability after RB interference in human fibroblasts
A. Amato, L. Lentini, T. Schillaci, A. Di Leonardo
Dept of Cellular and Developmental Biology (Palermo)
Micronuclei generation and chromosomal instability after RB interference in human fibroblasts
A. Amato, L. Lentini, T. Schillaci, A. Di Leonardo
Dept of Cellular and Developmental Biology (Palermo)
PMS.9 · 0+P7
Eukaryotic initiation Factor 6 is a rate-limiting controller of translation, growth and tumorigenesis
V. Gandin1, A. Miluzio1, A. Barbieri1, L. Magri1, P.C. Marchisio1, H. Kiyokawa2, S. Biffo1,3
1Molecular Histology and Cell Growth Unit, DIBIT-San Raffaele Hospital (Milan); 2Northwestern Univ, Feinberg School of Medicine (Chicago, USA); 3DISAV, Univ. Eastern Piedmont (Alessandria)
Eukaryotic initiation Factor 6 is a rate-limiting controller of translation, growth and tumorigenesis
V. Gandin1, A. Miluzio1, A. Barbieri1, L. Magri1, P.C. Marchisio1, H. Kiyokawa2, S. Biffo1,3
1Molecular Histology and Cell Growth Unit, DIBIT-San Raffaele Hospital (Milan); 2Northwestern Univ, Feinberg School of Medicine (Chicago, USA); 3DISAV, Univ. Eastern Piedmont (Alessandria)
PMS.9 · 0+P8
Interplay of Calmodulin, FADD and Casein Kinase Iα in apoptosis and mitosis
G. Papoff1, N. Trivieri1, R. Crielesi1, F. Ruberti2, S. Marsilio1, G. Ruberti1
1Istituto di Biologia Cellulare, CNR (Monterotondo); 2Istituto di Neurobiologia e Medicina Molecolare, CNR (Rome)
Interplay of Calmodulin, FADD and Casein Kinase Iα in apoptosis and mitosis
G. Papoff1, N. Trivieri1, R. Crielesi1, F. Ruberti2, S. Marsilio1, G. Ruberti1
1Istituto di Biologia Cellulare, CNR (Monterotondo); 2Istituto di Neurobiologia e Medicina Molecolare, CNR (Rome)
PMS.9 · P9
RanBP1 regulates mitotic microtubule stability and chromosome segregation
M. Ciciarello1, R. Mangiacasale1, A. Tedeschi1,2, E. Roscioli1, W. Rensen1, P. Lavia1
1Inst. Molecular Biology and Pathology, National Research Council, c/o Univ. Rome "La Sapienza" (Rome); 2Research Institute of Molecular Pathology (IMP) (Vienna, Austria)
RanBP1 regulates mitotic microtubule stability and chromosome segregation
M. Ciciarello1, R. Mangiacasale1, A. Tedeschi1,2, E. Roscioli1, W. Rensen1, P. Lavia1
1Inst. Molecular Biology and Pathology, National Research Council, c/o Univ. Rome "La Sapienza" (Rome); 2Research Institute of Molecular Pathology (IMP) (Vienna, Austria)
PMS.9 · P10
Delayed entry to quiescence in p21CDKN1A-null human fibroblasts: a possible involvement of DNA damage checkpoint
P. Perucca1, O. Cazzalini1, M. Savio1, T. Coppa1, R.A.L. Laskey3, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic, CNR (Pavia); 3Hutchison/MRC Research Centre (Cambridge, United Kingdom)
Delayed entry to quiescence in p21CDKN1A-null human fibroblasts: a possible involvement of DNA damage checkpoint
P. Perucca1, O. Cazzalini1, M. Savio1, T. Coppa1, R.A.L. Laskey3, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic, CNR (Pavia); 3Hutchison/MRC Research Centre (Cambridge, United Kingdom)
PMS.9 · P11
The involvement of the proteasomal protein Rpn11 in the FEAR pathway activation and in rDNA segregation in S. cerevisiae
T. Rinaldi, M. Esposito, L. Frontali
Dept Cell and Developmental Biology (Rome)
The involvement of the proteasomal protein Rpn11 in the FEAR pathway activation and in rDNA segregation in S. cerevisiae
T. Rinaldi, M. Esposito, L. Frontali
Dept Cell and Developmental Biology (Rome)
PMS.9 · P12
Interplay between typical and atypical Arabidopsis E2Fs in cell cycle progression and development
C. Maggio1, R. Sozzani1, L. Concia1, P. Longoni1, C. Bergounioux2, R. Giordo3, D. Albani3, R. Cella1
1Dip. di Genetica e Microbiologia (Pavia); 2Inst. of Plant Biotechnology (Orsay, France); 3Dip. di Botanica ed Ecologia Vegetale (Sassari)
Interplay between typical and atypical Arabidopsis E2Fs in cell cycle progression and development
C. Maggio1, R. Sozzani1, L. Concia1, P. Longoni1, C. Bergounioux2, R. Giordo3, D. Albani3, R. Cella1
1Dip. di Genetica e Microbiologia (Pavia); 2Inst. of Plant Biotechnology (Orsay, France); 3Dip. di Botanica ed Ecologia Vegetale (Sassari)
PMS.9 · P13
Uncapped telomeres activate multiple cell cycle checkpoints in Drosophila
M. Musarò1, L. Ciapponi2, B. Fasulo3, M. Gatti2, G. Cenci1
1DiSTeBA (Lecce); 2Dip. di Genetica e Biologia Molecolare, Univ. di Roma "La Sapienza" (Rome); 3Molecular Cell and Developmental Biology, Univ. of California (Santa Cruz, CA, USA)
Uncapped telomeres activate multiple cell cycle checkpoints in Drosophila
M. Musarò1, L. Ciapponi2, B. Fasulo3, M. Gatti2, G. Cenci1
1DiSTeBA (Lecce); 2Dip. di Genetica e Biologia Molecolare, Univ. di Roma "La Sapienza" (Rome); 3Molecular Cell and Developmental Biology, Univ. of California (Santa Cruz, CA, USA)
PMS.9 · P14
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts
L. Lentini, L. Insalaco, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
Transient silencing of MAD2 induces mitotic abnormalities and p21waf1 overexpression in primary human fibroblasts
L. Lentini, L. Insalaco, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
PMS.9 · P15
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture
L. Insalaco, L. Lentini, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
Low doses of Hydroxyurea induce centrosome amplification and aneuploidy in primary human fibroblasts in culture
L. Insalaco, L. Lentini, A. Amato, T. Schillaci, A.D. Leonardo
Dept of Cellular and Developmental Biology "A.Monroy", Univ. Palermo (Palermo)
PMS.9 · P16
Antiproliferative activity of the new Resveratrol-derivative 4, 4’-dihydroxy-stilbene
L. Bianchi1, M. Savio1, T. Coppa1, O. Cazzalini1, M.C. Lazzč1, P. Perruca1, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic,CNR (Pavia)
Antiproliferative activity of the new Resveratrol-derivative 4, 4’-dihydroxy-stilbene
L. Bianchi1, M. Savio1, T. Coppa1, O. Cazzalini1, M.C. Lazzč1, P. Perruca1, E. Prosperi2, L.A. Stivala1
1Dept Experimental Medicine, Univ. Pavia (Pavia); 2Institute of Molecular Genetic,CNR (Pavia)
PMS.9 · P17
Differenet intracellular pathways are involved in mitosis dysregulation induced by HCV and ethanol
C. Balsano1,2, A. Alisi1,2, M. Ghidinelli1,2, A. Spaziani1,2
1Dept Medicina Interna e Sanità Pubblica (L'Aquila); 2 A. Cesalpino Foundation (Rome )
Differenet intracellular pathways are involved in mitosis dysregulation induced by HCV and ethanol
C. Balsano1,2, A. Alisi1,2, M. Ghidinelli1,2, A. Spaziani1,2
1Dept Medicina Interna e Sanità Pubblica (L'Aquila); 2 A. Cesalpino Foundation (Rome )
PMS.9 · P18
Thyroid hormone T3 : dual effect on proliferation in human endocrine tumor cells
S. Michienzi1,2, G. Moriggi1,2, C. Verga Falzacappa1,2, V. Patriarca1,2, C. Mangialardo1,2, A. Stigliano1,2, V. Toscano1, S. Misiti1,2
1Chair of Endocrinology, II Faculty of Medicine, Sapienza, Univ. Rome (Rome); 2Centro Ricerca AFaR, Ospedale San Pietro FBF (Rome)
Thyroid hormone T3 : dual effect on proliferation in human endocrine tumor cells
S. Michienzi1,2, G. Moriggi1,2, C. Verga Falzacappa1,2, V. Patriarca1,2, C. Mangialardo1,2, A. Stigliano1,2, V. Toscano1, S. Misiti1,2
1Chair of Endocrinology, II Faculty of Medicine, Sapienza, Univ. Rome (Rome); 2Centro Ricerca AFaR, Ospedale San Pietro FBF (Rome)
PMS.9 · P19
The cytoplasmic tyrosine kinase Fes is a crucial mediator of the EGFR signaling in neuroblastoma cells
E. Brunelli, I. Gnemmi, L. Mercantili, G. Pinton, P.L. Canonico, F. Condorelli, L. Moro
Dept DiSCAFF (Novara)
The cytoplasmic tyrosine kinase Fes is a crucial mediator of the EGFR signaling in neuroblastoma cells
E. Brunelli, I. Gnemmi, L. Mercantili, G. Pinton, P.L. Canonico, F. Condorelli, L. Moro
Dept DiSCAFF (Novara)
PMS.9 · P20
Role of Ng2 and Olig2 in PDGF-B induced mouse oligodendroglioma model
M. Terrile1,2, I. Apolloni1,2, P. Malatesta1,2
1National Inst. for Cancer Reasearch (Genoa); 2Dept of Oncology, Biology and Genetics (Genoa)
Role of Ng2 and Olig2 in PDGF-B induced mouse oligodendroglioma model
M. Terrile1,2, I. Apolloni1,2, P. Malatesta1,2
1National Inst. for Cancer Reasearch (Genoa); 2Dept of Oncology, Biology and Genetics (Genoa)
PMS.9 · P21
AP-2α and AP-2γ regulate chemotherapy-induced apoptosis in epithelial tumors
E. Penna1, F. Orso1, P. Sismondi1, M. de Bortoli1,2, D. Taverna1,2
1Dept Oncological Science, Univ. Torino and Inst. for Cancer Research and Treatment (IRCC) (Torino); 2Centro Interdipartimentale Sistemi Complessi in Biologia e Medicina Molecolare c/o DBAU (Torino)
AP-2α and AP-2γ regulate chemotherapy-induced apoptosis in epithelial tumors
E. Penna1, F. Orso1, P. Sismondi1, M. de Bortoli1,2, D. Taverna1,2
1Dept Oncological Science, Univ. Torino and Inst. for Cancer Research and Treatment (IRCC) (Torino); 2Centro Interdipartimentale Sistemi Complessi in Biologia e Medicina Molecolare c/o DBAU (Torino)
PMS.9 · P22
Different functional role of V600E BRAF mutation in acquired nevi and cutaneous melanomas
M. Scatolini1, M. Mellogrand1, F. Acquadro3, E. Grosso1,2, T. Venesio4, M. Risio4, G. Chiorino1
1Fondo Edo Tempia (Biella); 2SysBiom (Turin); 3C.N.I.O. (Madrid, Spain); 4I.R.C.C. (Candiolo)
Different functional role of V600E BRAF mutation in acquired nevi and cutaneous melanomas
M. Scatolini1, M. Mellogrand1, F. Acquadro3, E. Grosso1,2, T. Venesio4, M. Risio4, G. Chiorino1
1Fondo Edo Tempia (Biella); 2SysBiom (Turin); 3C.N.I.O. (Madrid, Spain); 4I.R.C.C. (Candiolo)
PMS.9 · P23
AcP1 gene and cancerogenesis.
D. Cirelli1, E. Caproni1, R. Marzocchini1, F. Malentacchi2, G. Pepe3, G. Raugei1
1Dept Biochemical Sciences, Univ. Florence (Florence); 2Dept Clinical Physiopathology, Univ. Florence (Florence); 3Dept Medical and Surgical Critical Care, Univ. Florence (Florence)
AcP1 gene and cancerogenesis.
D. Cirelli1, E. Caproni1, R. Marzocchini1, F. Malentacchi2, G. Pepe3, G. Raugei1
1Dept Biochemical Sciences, Univ. Florence (Florence); 2Dept Clinical Physiopathology, Univ. Florence (Florence); 3Dept Medical and Surgical Critical Care, Univ. Florence (Florence)
PMS.9 · P24
Inflammation-associated centrosomal lesions in esophageal stem cells and their progenies
D. Segat1, E. Dazzo1, M. Cassaro2, C. Romualdi1, M. Rugge3, E. Ancona3, G. Zaninotto4, M.D. Baroni1
1Dept of Biology, Univ. Padua (Padua); 2Dept of Oncological and Surgical Science, Univ. of Padua (Padua); 3Dept of Endoscopy and Pathology and Dept of Surgery, Istituto Oncologico Veneto I.R.C.S.S. (Padua); 4Dept of General Surgery, S. Giovanni e Paolo Hospital (Venice)
Inflammation-associated centrosomal lesions in esophageal stem cells and their progenies
D. Segat1, E. Dazzo1, M. Cassaro2, C. Romualdi1, M. Rugge3, E. Ancona3, G. Zaninotto4, M.D. Baroni1
1Dept of Biology, Univ. Padua (Padua); 2Dept of Oncological and Surgical Science, Univ. of Padua (Padua); 3Dept of Endoscopy and Pathology and Dept of Surgery, Istituto Oncologico Veneto I.R.C.S.S. (Padua); 4Dept of General Surgery, S. Giovanni e Paolo Hospital (Venice)
PMS.9 · P25
Targeting ID proteins with an HLH mutant domain triggers neuronal commitment and differentiation of NB cells
D. Annibali1, R. Ciarapica2, R. Rota2, S. Nasi1
1IBPM, CNR (Rome); 2Ospedale Pediatrico Bambino Gesù (Roma)
Targeting ID proteins with an HLH mutant domain triggers neuronal commitment and differentiation of NB cells
D. Annibali1, R. Ciarapica2, R. Rota2, S. Nasi1
1IBPM, CNR (Rome); 2Ospedale Pediatrico Bambino Gesù (Roma)
PMS.9 · P26
New tools for study and treatment of malignant pleural mesothelioma
S. Soligon1, A. Daga2, L. Mutti3, G. Corte2, G. Gaudino1
1DISCAFF, Univ. del Piemonte Orientale (Novara); 2Univ. of Genoa, IST (Genoa); 3ASL 11 (Vercelli)
New tools for study and treatment of malignant pleural mesothelioma
S. Soligon1, A. Daga2, L. Mutti3, G. Corte2, G. Gaudino1
1DISCAFF, Univ. del Piemonte Orientale (Novara); 2Univ. of Genoa, IST (Genoa); 3ASL 11 (Vercelli)
PMS.9 · P27
Antiproliferative and proapoptotic effects of a new combi-molecule on non small cell lung cancer cell lines
R. Alfieri1, A. Cavazzoni1, C. Carmi2, M. Galetti1, V. Zuliani2, C. Fumarola1, M. Mor2, P.G. Petronini1
1Dept Experimental Medicine, Univ. Parma (Parma); 2Pharmaceutical Dept, Univ. Parma (Parma)
Antiproliferative and proapoptotic effects of a new combi-molecule on non small cell lung cancer cell lines
R. Alfieri1, A. Cavazzoni1, C. Carmi2, M. Galetti1, V. Zuliani2, C. Fumarola1, M. Mor2, P.G. Petronini1
1Dept Experimental Medicine, Univ. Parma (Parma); 2Pharmaceutical Dept, Univ. Parma (Parma)
PMS.9 · P28
Keratinocyte cultures from involved skin in vitiligo patients show an impaired in vitro behaviour
E. Migliore, S. Bondanza, R. Maurelli, P. Paterna, G. Primavera, E. Paionni, E. Dellambra, L. Guerra
IDI-IRCSS Roma, Lab. Ing. Tissut. e Fisiopat. Cutanea (Rome)
Keratinocyte cultures from involved skin in vitiligo patients show an impaired in vitro behaviour
E. Migliore, S. Bondanza, R. Maurelli, P. Paterna, G. Primavera, E. Paionni, E. Dellambra, L. Guerra
IDI-IRCSS Roma, Lab. Ing. Tissut. e Fisiopat. Cutanea (Rome)
PMS.9 · P29
Impaired differentiation in plantar keratinocytes from Rspo mutated - XX sex reversal patient
L. Panacchia1, O. Radi2, P. Parma2, S. Bondanza1, R. Maurelli1, E. Dellambra1, G. Camerino2, L. Guerra1
1Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI-IRCCS, Pomezia (Rome); 2Dip. di Patologia Umana ed Ereditaria, Sezione di Biologia Generale e Genetica Medica, Univ. di Pavia (Pavia)
Impaired differentiation in plantar keratinocytes from Rspo mutated - XX sex reversal patient
L. Panacchia1, O. Radi2, P. Parma2, S. Bondanza1, R. Maurelli1, E. Dellambra1, G. Camerino2, L. Guerra1
1Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI-IRCCS, Pomezia (Rome); 2Dip. di Patologia Umana ed Ereditaria, Sezione di Biologia Generale e Genetica Medica, Univ. di Pavia (Pavia)
PMS.9 · P30
Haplotypes and activities of the internal promoter for the isoform ΔN133 of TP53
I. Bellini1, L. Pitto2, G. Rainaldi2, F. Gemignani1, S. Landi1
1Dip. Biologia, Univ. Pisa (Pisa); 2Istituto di Fisiologia Clinica del CNR di Pisa (Pisa)
Haplotypes and activities of the internal promoter for the isoform ΔN133 of TP53
I. Bellini1, L. Pitto2, G. Rainaldi2, F. Gemignani1, S. Landi1
1Dip. Biologia, Univ. Pisa (Pisa); 2Istituto di Fisiologia Clinica del CNR di Pisa (Pisa)
PMS.9 · P31
Molecular combing for the detection of rearrangements involving the human APC locus
V. Biscaro1, M. Bensi1, E. Molino1, A. Castelli1, L. Varesco2, G.N. Ranzani1, E. Raimondi1
1Dept Genetics and Microbiology, Univ. Pavia (Pavia); 2Natl Inst Cancer Res (Genoa)
Molecular combing for the detection of rearrangements involving the human APC locus
V. Biscaro1, M. Bensi1, E. Molino1, A. Castelli1, L. Varesco2, G.N. Ranzani1, E. Raimondi1
1Dept Genetics and Microbiology, Univ. Pavia (Pavia); 2Natl Inst Cancer Res (Genoa)
PMS.9 · P32
Knock down of ATM and ATR induces p53 displacement from centrosomes in human primary cells
R. Burla1, P. Caruso1, S. Piersanti1,2, C. Remoli1,2, E. Cundari1,3, I. Saggio1,2,3
1Dept of Genetics and Molecular Biology, Univ. of Rome "La Sapienza” (Rome); 2Fondazione Parco San Raffaele (Rome); 3IBPM CNR (Rome)
Knock down of ATM and ATR induces p53 displacement from centrosomes in human primary cells
R. Burla1, P. Caruso1, S. Piersanti1,2, C. Remoli1,2, E. Cundari1,3, I. Saggio1,2,3
1Dept of Genetics and Molecular Biology, Univ. of Rome "La Sapienza” (Rome); 2Fondazione Parco San Raffaele (Rome); 3IBPM CNR (Rome)
PMS.9 · P33
Biochemical and immunohistochemical characterization of human RNASET2 expression
P. Campomenosi1, S. Salis1, C. Riva2, S. Marchet2, L. Giuliani1, C. Lindqvist3, F. Acquati1, L. Monti1, C. Capella2, R. Taramelli1
1Dept Biotechnologies and Molecular Sciences, Univ. Insubria (Varese); 2Dept of AnathomoPathology, Univ. of Insubria (Varese); 3Dept of Biochemistry and Pharmacy, Abo Akademi Univ. (Turku, Finland)
Biochemical and immunohistochemical characterization of human RNASET2 expression
P. Campomenosi1, S. Salis1, C. Riva2, S. Marchet2, L. Giuliani1, C. Lindqvist3, F. Acquati1, L. Monti1, C. Capella2, R. Taramelli1
1Dept Biotechnologies and Molecular Sciences, Univ. Insubria (Varese); 2Dept of AnathomoPathology, Univ. of Insubria (Varese); 3Dept of Biochemistry and Pharmacy, Abo Akademi Univ. (Turku, Finland)
PMS.9 · P34
HIPK2 contributes to the divergent cell responses elicited by the specific p53 inducers RITA and Nutlin-3
C. Rinaldo1, A. Prodosmo1, F. Siepi1, A. Sacchi1, G. Selivanova2, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst. (Rome); 2Dept Microbiology, Tumor and Cell Biology, Karolinska Inst (Stockholm, Sweden)
HIPK2 contributes to the divergent cell responses elicited by the specific p53 inducers RITA and Nutlin-3
C. Rinaldo1, A. Prodosmo1, F. Siepi1, A. Sacchi1, G. Selivanova2, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst. (Rome); 2Dept Microbiology, Tumor and Cell Biology, Karolinska Inst (Stockholm, Sweden)
PMS.9 · P35
p53-independent mechanisms of HIPK2 induced sensitivity to antineoplastic drugs
C. Lazzari1, A. Prodosmo1, A. Costanzo2, A. Sacchi1, L. Guerrini3, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst (Roma); 2Dept Dermatology, Univ. Tor Vergata Rome (Rome); 3Dept Biomolecular and Biotechnological Sciences, Univ. Milan (MIlan)
p53-independent mechanisms of HIPK2 induced sensitivity to antineoplastic drugs
C. Lazzari1, A. Prodosmo1, A. Costanzo2, A. Sacchi1, L. Guerrini3, S. Soddu1
1Dept Experimental Oncology, Regina Elena Cancer Inst (Roma); 2Dept Dermatology, Univ. Tor Vergata Rome (Rome); 3Dept Biomolecular and Biotechnological Sciences, Univ. Milan (MIlan)
PMS.9 · P36
PRDM1/BLIMP1 & PRDM2/RIZ in T CD4+ naïve lymphocytes activation
L. de Felice1, C. de Rosa1, M. Pacifico1, E. Di Zazzo1, N. Medici1, B. Moncharmont2, G. Matarese3, C. Abbondanza1
1Dip. Patologia generale, Seconda Univ. Napoli (Napoli); 2Dip. di Scienze per la Salute, Univ. degli Studi del Molise (Campobasso); 3Ist. di Endocrinologia e Oncologia Sperimentale, CNR (Napoli)
PRDM1/BLIMP1 & PRDM2/RIZ in T CD4+ naïve lymphocytes activation
L. de Felice1, C. de Rosa1, M. Pacifico1, E. Di Zazzo1, N. Medici1, B. Moncharmont2, G. Matarese3, C. Abbondanza1
1Dip. Patologia generale, Seconda Univ. Napoli (Napoli); 2Dip. di Scienze per la Salute, Univ. degli Studi del Molise (Campobasso); 3Ist. di Endocrinologia e Oncologia Sperimentale, CNR (Napoli)
PMS.9 · P37
8-prenylnaringenin inhibits epidermal growth factor induced MCF-7 breast cancer cells proliferation targeting PI3K activity
G. Pinton, E. Brunelli, A. Minassi, G. Appendino, L. Moro
Dept DiSCAFF (Novara)
8-prenylnaringenin inhibits epidermal growth factor induced MCF-7 breast cancer cells proliferation targeting PI3K activity
G. Pinton, E. Brunelli, A. Minassi, G. Appendino, L. Moro
Dept DiSCAFF (Novara)
PMS.9 · P38
Study of the biological action of two tomato cysteine-rich peptides on human endothelial and carcinoma cells
C. Cavallini1, B. Molesini1, M. Vezzalini3, C. Sorio3, P. Delva4, P. Minuz4, T. Pandolfini2, A. Spena1
1Dept Scientific Technological, Univ. Verona (Verona); 2Dept DiSTeMeV, Univ. of Verona (Verona); 3Dept of Pathology, Univ. of Verona (Verona); 4Dept Biomedical and Surgical Sciences, Univ. of Verona (Verona)
Study of the biological action of two tomato cysteine-rich peptides on human endothelial and carcinoma cells
C. Cavallini1, B. Molesini1, M. Vezzalini3, C. Sorio3, P. Delva4, P. Minuz4, T. Pandolfini2, A. Spena1
1Dept Scientific Technological, Univ. Verona (Verona); 2Dept DiSTeMeV, Univ. of Verona (Verona); 3Dept of Pathology, Univ. of Verona (Verona); 4Dept Biomedical and Surgical Sciences, Univ. of Verona (Verona)
PMS.9 · P39
Corylus avellana species as a new source of Taxol and taxanes to be used as antimitotic drug
L. Ottaggio1, F. Bestoso2, M. Sancandi2, M. Miele2,3
1National Inst. for Cancer Research (Genova); 2Laboratory of Plant and Pharmaceutical Biotechnology, Advanced Biotechnology Center (ABC) (Genova); 3Dept of Pharmaceutical Sciences, Univ. of Genova (Genova)
Corylus avellana species as a new source of Taxol and taxanes to be used as antimitotic drug
L. Ottaggio1, F. Bestoso2, M. Sancandi2, M. Miele2,3
1National Inst. for Cancer Research (Genova); 2Laboratory of Plant and Pharmaceutical Biotechnology, Advanced Biotechnology Center (ABC) (Genova); 3Dept of Pharmaceutical Sciences, Univ. of Genova (Genova)
PMS.9 · P40
Diacylglycerol kinase is required for estrogen-induced proliferation, motility, and anoikis of endometrial cancer cells
I. Gregnanin1, P.E. Porporato2, B. Perego1, F. Chianale2, A. Romano1, A. Graziani2, N. Surico1, N. Filigheddu1
1Dept Clinical and Experimental Medicine, Univ Piemonte Orientale (Novara); 2Dept Medical Sciences, Univ Piemonte Orientale (Novara)
Diacylglycerol kinase is required for estrogen-induced proliferation, motility, and anoikis of endometrial cancer cells
I. Gregnanin1, P.E. Porporato2, B. Perego1, F. Chianale2, A. Romano1, A. Graziani2, N. Surico1, N. Filigheddu1
1Dept Clinical and Experimental Medicine, Univ Piemonte Orientale (Novara); 2Dept Medical Sciences, Univ Piemonte Orientale (Novara)
PMS.9 · P41
Loss of Chp-1 (CHORD-containing protein 1) results in early embryonic lethality due to aneuploidy and mitotic defects
R. Ferretti1, V. Palumbo2, A. Di Savino1, S. Velasco1, S. Bonaccorsi2, M. Gatti2, G. Tarone1, M. Brancaccio1
1Dip. Genetica, Biologia e Biochimica, Univ. Torino (Turin); 2Insitute of Biology and Molecular Pathology CNR, and Dept of Genetics and Molecular Biology, Univ. of Rome “La Sapienza” (Rome)
Loss of Chp-1 (CHORD-containing protein 1) results in early embryonic lethality due to aneuploidy and mitotic defects
R. Ferretti1, V. Palumbo2, A. Di Savino1, S. Velasco1, S. Bonaccorsi2, M. Gatti2, G. Tarone1, M. Brancaccio1
1Dip. Genetica, Biologia e Biochimica, Univ. Torino (Turin); 2Insitute of Biology and Molecular Pathology CNR, and Dept of Genetics and Molecular Biology, Univ. of Rome “La Sapienza” (Rome)