PMS 4 · DNA repair and mutagenesis
Thursday .::. 27 September .::. 14:00-16:00

PMS.4 · 0+P1    

Genotoxicity profile of two commercial antiprotozoan/antibacterial drugs
A. Buschini, F. Giordani, M. Lazzaretti, A. Mancini, C. Rossi, P. Poli
Dept Genetics, Biology of microrganisms, Anthropology, Evolution (Parma)

PMS.4 · 0+P2    

Molecular characterization of hprt mutations induced by Me-lex in CHO-9 cell line
D. Russo¹, P. Menichini¹, P. Monti¹, A. Inga¹, B. Gold², G. Fronza^1
1Molecular Mutagenesis Unit, Dept of Translational Oncology, Nat. Inst. for Cancer Res., IST (Genoa); ²Dept of Pharmaceutical Sciences, Univ. of Pittsburgh, Pittsburgh, PA, USA

PMS.4 · 0+P3    

Chemopotentiation of cisplatin toxicity by poly(ADPR)polymerases inhibitor PJ34 in carcinoma cell
N. Gambi, F. Tramontano, P. Quesada
Dept Structural and Functional Biology, Univ. Federico II of Naples (Naples)

PMS.4 · 0+P4    

Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis in males
F. Coppede'¹, G. Siciliano¹, L. Murri¹, L. Migliore^2
1Univ. Pisa, Dept of Neurosciences (Pisa); ²Dept of Human and Environmental Sciences, Univ. of Pisa (Pisa)

PMS.4 · 0+P5    

Spatial distribution and interaction of p21^CDKN1A and PARP-1 in base excision repair
O. Cazzalini², P. Perucca², L.A. Stivala², A.I. Scovassi¹, E. Prosperi^1
1Inst. Molecular Genetics CNR, Histochemistry and Cytometry section (Pavia); ²Dept of Exptl. Medicine, General Pathology, Univ. of Pavia (Pavia)

PMS.4 · 0+P6    

Multifaceted involvement of the CSA protein in the removal of DNA damage
B. Vaz¹, E. Botta¹, P. Degan², R. Catera¹, M.A. Pedrini¹, M. Stefanini^1
1Istituto di Genetica Molecolare, CNR (Pavia); ²Istituto Nazionale per la Ricerca sul Cancro di Genova, IST-CBA (Genoa)

PMS.4 · 0+P7    

DNA ligase I deficiency activates the ATM-dependent DNA damage checkpoint and affects cell adhesion
S. Soza, I. Monoli, E. Buoso, G. Biamonti, A. Montecucco
IGM-CNR (Pavia)

PMS.4 · 0+P8    

Role of the interaction between NBS1 and γ-H2AX in the DNA double strand break response
A. Di Masi, M. Viganotti, A. Antoccia, F. Polticelli, C. Tanzarella
Dept Biology, Univ. "Roma Tre", (Rome)

PMS.4 · P9    

Genotoxicity of migrated compounds from PET bottles into mineral water
E. Ceretti¹, D. Feretti¹, I. Zerbini¹, M. Scaglia², S. Monarca³, A. Dalmiglio², F. Donato^1
1Dept of Experimental and Applied Medicine, Section of Hygiene, Epidemiology and Public Health, Univ. Brescia (Brescia); ²ARPA Regional Environmental Agency of Brescia (Brescia); ³Dept of Surgical and Medical Specialities and Public Health, Univ. of Perugia (Perugia)

PMS.4 · P10    

Toxicity of carbon nanomaterials with in vitro RAW 264.7 macrophages: a model for genotoxicity from nanoparticles
M.L.D. Giorgio¹, A.M. Ragnelli¹, A. Galano¹, P.P. Aimola¹, L. Arrizza², P. Picozzi³, A. Poma^1
1Dept Basic and Applied Biology, Univ. L'Aquila (L'Aquila); ²Microscopy Center UNIVAQ (Coppito); ³Physics Department UNIVAQ (Coppito)

PMS.4 · P11    

Interaction of nanomaterials with biological systems: genotoxicity studies of carbon nanotubes on human peripheral lymphocytes
M.R. D'Errico¹, A. Bonelli¹, R. Colognato¹, R. Arici¹, E. Bergamaschi², S. Bellucci³, L. Migliore^1
1Dept of Human and Environmental Sciences (Pisa); ²Laboratory of Industrial Toxicology, Univ. of Parma (Parma); ³National Institute of Phisics (Frascati )

PMS.4 · P12    

Distribution of genotoxic compounds in size-segregated PM fractions from an elevated car transit area in Catania (Italy)
V. Librando², Z. Minniti², S. D'Amico², G. Perrini², C. Federico¹, A. Motta², S. Motta¹, S. Saccone^1
1Dept Biologia Animale "M. La Greca", Univ. Catania (Catania); ²Dept Scienze Chimiche, Univ. of Catania (Catania)

PMS.4 · P13    

Comet Assay interlaboratory comparison for human biomonitoring
F. Mussi¹, M. Villarini², E. Ceretti³, A. Buschini¹, M. Moretti², D. Feretti³, L. Dominici², C. Rossi¹, P. Poli¹, S. Monarca^2
1Dept GBMAE, Univ. Parma (Parma); ²Dept Medical-Surgical Specialities and Public Health, Univ. Perugia (Perugia); ³Dept of Experimental and Applied Medicine, Univ. Brescia (Brescia)

PMS.4 · P14    

Radiation quality effect on telomere elongation of irradiated mammalian cells
F. Berardinelli¹, F. Marullo¹, A. Sgura¹, A. Antoccia¹, G. Cuttone², R. Cherubini³, S. Gerardi³, C. Tanzarella^1
1Dept Biology, Univ. "Roma Tre" (Rome); ²INFN-Laboratori Nazionali del Sud, LNS (Catania); ³INFN-Laboratori Nazionali di Legnaro, LNL (Legnaro)

PMS.4 · P15    

Influence of MDR1 polymorphisms on the outcome of Multiple Myeloma
V. Maggini¹, G. Buda², R. Barale¹, S. Galimberti², A. Martino¹, F. Morabito³, E. Orciuolo², M. Petrini², A.M. Rossi^1
1Dept Biology, Pisa Univ. (Pisa); ²Dept of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa Univ. (Pisa); ³Haematology Service, S. Annunziata Hospital (Cosenza)

PMS.4 · P16    

Interaction of genetic and environmental factors in the cervical cancer individual susceptibility
S. Palma¹, L. Mariani², A. Venuti³, G. Prignano⁴, P. Cordiali⁴, E. Trento⁴, A. Arancio⁴, A. Testa^1
1Sect Toxicology and Biomedical Sciences, ENEA Casaccia (Rome); ²Ginecology Oncology, National Institute of Cancer, Regina Elena (Rome); ³Virology Laboratory, National Institute of Cancer Regina Elena (Rome); ⁴SSO Microbiology and Immunology Diagnostic IRCCS Institute San Gallicano (Rome)

PMS.4 · P17    

Fragile site FRA1H and transcriptional profiling of genes located within this region in tumor-derived cell lines
A. Curatolo, Z.M. Limongi, F. Pelliccia, N. Bosco, A. Rocchi
Dept Genetics and Molecular Biology, Univ. La Sapienza Rome (Rome)

PMS.4 · P18    

A role for HMGB1 in the maintenance of genome stability
B. Celona, M.E. Bianchi, A. Agresti
Chromatin Dynamics Unit, San Raffaele Scientific Inst. (Milan)

PMS.4 · P19    

Decline of Base Excision Repair (BER) efficiency in primary human keratinocytes during aging
R. Maurelli¹, M.R. D'Errico², S. Cordisco¹, P. Degan³, L. Guerra¹, E. Dogliotti², E. Dellambra^1
1Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI - IRCCS (Pomezia, Rome); ²Dept of Environment and Primary Prevention, Istituto Superiore di Sanità (Rome); ³Italian National Cancer Institute, IST (Genoa)

PMS.4 · P20    

Phenotypic reversion of human keratinocytes from a patient suffering from Cockayne Syndrome (CS)
S. Cordisco¹, R. Maurelli¹, S. Bondanza¹, T. Nardo², P. Degan³, M. Stefanini², L. Guerra¹, E. Dellambra^1
1Laboratory of Tissue Engineering and Cutaneous Physiopathology, IDI - IRCCS (Pomezia, Rome); ²Istituto di Genetica Molecolare, CNR (Pavia); ³Italian National Cancer Institute, IST, (Genova)

PMS.4 · P21    

Degradation of p21CDKN1A in response to DNA damaging agents is a specific NER-dependent process in human cells
T. Coppa¹, M. Savio¹, L.A. Stivala¹, V. Vannini¹, E. Prosperi^2
1Dept Experimental Medicine (Pavia); ²Institute of Molecular Genetic (Pavia)

PMS.4 · P22    

Is there a role of oxidative DNA damage in Cockayne syndrome and trichothiodystrophy?
T.A. Lemma¹, P. Degan², A. Calcagnile¹, M. Teson³, E. Botta⁴, M. Stefanini⁴, E. Dogliotti¹, M. D'Errico^1
1Istituto Superiore di Sanità (Rome); ²Istituto Nazionale per la Ricerca sul Cancro (Genova); ³Istituto Dermopatico dell'Immacolata (Rome); ⁴Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (Pavia)

PMS.4 · P23    

Biological dosimetry: the use of micronuclei frequency as quantitative indicator of X-rays induced chromosomal damage
C. Bolognesi¹, C. Balia¹, P. Roggieri¹, F. Sorcinelli¹, F. Cardinali², P. Bruzzi^2
1Environmental Carcinogenesis Unit, National Cancer Research Inst. (Genoa); ²Clinical Epidemiology, National Cancer Research Institute (Genoa)